The outbreak of Ebola Virus Disease (EVD) in West Africa during 2014-2015 was an unprecedented modern crisis that required novel approaches to outbreak containment and management. In response, the Ministry of Health and Sanitation (MOHS) and the King’s Sierra Leone Partnership (KSLP) in Freetown, Sierra Leone, worked to develop and implement five new Ebola Holding Units (EHUs) in government hospitals, which successfully isolated 37% of the 3,097 confirmed EVD cases within the country’s Western Urban and Rural district.