While risks of handling pathogens in a laboratory can be well-characterized, controlled and mitigated, the risks in healthcare setting are much more difficult to control. We’ll identify the risks in healthcare settings and how to reduce them – beyond what’s currently seen in the ER intake and biocontainment patient suites – by applying fundamental facility design principles related to biocontainment. The presentation will evaluate existing and new facilities designed for patient safety, and discuss lessons learned and modifications that can improve safety.