With no known precedent, Children’s Hospital of Philadelphia pursued a vision to develop a new pediatric patient care unit: one that would meet the requirements and licensure of an acute care unit, but would provide a safe and supportive environment for patients with a comorbid developmental, behavioral, or psychiatric diagnosis. A multidisciplinary team worked together to envision, plan, and design an environment to support a new model of care for this unique population. Key elements of the project—a remodel of an existing unit—include patient, family, and staff health; circadian lighting; biophilic design; and safety.