By combining observation, interviews, simulation, and rapid prototyping, this team developed design solutions that help healthcare workers stay safe while engaged in challenging tasks. This webinar brings the experience of the healthcare practitioners who cared for Ebola patients during the 2014 outbreak and introduces a human-centered discovery approach developed by design researchers at SimTigrate Design Lab to define the design requirements of spaces where the risk of self- and cross-contamination is the highest. In this presentation, presenters will share the results of the second phase of a large research study funded by the CDC on doffing of personal protective equipment (PPE) and guidelines for the design of critical environments.